Severity: Notice
Message: Trying to get property of non-object
Filename: controllers/VThunter.php
Line Number: 393
Backtrace:
File: /data/VThunterPlots/VThunter/application/controllers/VThunter.php
Line: 393
Function: _error_handler
File: /data/VThunterPlots/VThunter/index.php
Line: 315
Function: require_once
Severity: Notice
Message: Trying to get property of non-object
Filename: controllers/VThunter.php
Line Number: 394
Backtrace:
File: /data/VThunterPlots/VThunter/application/controllers/VThunter.php
Line: 394
Function: _error_handler
File: /data/VThunterPlots/VThunter/index.php
Line: 315
Function: require_once
Severity: Notice
Message: Trying to get property of non-object
Filename: controllers/VThunter.php
Line Number: 395
Backtrace:
File: /data/VThunterPlots/VThunter/application/controllers/VThunter.php
Line: 395
Function: _error_handler
File: /data/VThunterPlots/VThunter/index.php
Line: 315
Function: require_once
Summary: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0049 | 2021.04 | 10X Genomics | Lung | Normal | 1702 | Link |
| Vthunter_110082 | 2018.05 | Drop-seq | Pallium | Normal | 4187 | Link |
Featureplot of receptors
Expression: Biased expression in duodenum (RPKM 1193.1), small intestine (RPKM 1007.5) and 5 other tissues?
